neuronal nicotinic receptors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9787	Suvn-911		AChR
	suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.		AChR
T9076	Spinosad		Others
	Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nicotinic acetylcholinester...		Others
T60080	TMPH	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR
	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.		AChR
T2285	Encenicline hydrochloride	EVP-6124 (hydrochloride),EVP-6124 hydrochloride	AChR
	Encenicline hydrochloride (EVP-6124 hydrochloride) is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).		AChR
T7884	NS 1738	NSC 213859	AChR
	NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)		AChR
TP2063	α-Conotoxin MII		AChR
	α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuro...		AChR
T22735	DMAB-anabaseine dihydrochloride	N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride	AChR
	DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) is an α7-containing neuronal nicotinic receptor partial agonist and an antagonist at α...		AChR
TP2063L	α-Conotoxin MII acetate	α-Conotoxin MII acetate (175735-93-0 Free base)	AChR
	α-Conotoxin MII acetate is a 16-amino acid peptide from the venom of the marine snail Conus magus. α-Conotoxin MII acetate potently blocks nicotinic acetylcholine receptors composed of α3β2 subunits, with an IC50 of 0.5 ...		AChR
T0086	Galanthamine hydrobromide	Galantamine hydrobromide,Galanthamine HBr	AChR , AChE
	Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.		AChR , AChE
T30248	AZD 3043	TD 4756,THRX 918661,AZD-3043,AZD3043	GABA Receptor
	AZD 3043 (THRX 918661) is a variant modulator of the γ-aminobutyric acid type A receptor, a novel sedative-hypnotic and a potential short-acting anesthetic that produces hypnosis and EEG suppression in rats.AZD 3043 pote...		GABA Receptor
T16281	Nelonicline	ABT-126	Adenosine Receptor
	Nelonicline is a selective agonist of neuronal nicotinic receptors.		Adenosine Receptor
T23462	TMPH hydrochloride		Others
	neuronal nicotinic ACh receptors (nAChRs) antagonist		Others
T29916	Altinicline
	Altinicline can bine with neuronal nicotinic acetylcholine receptors; SIB-1765F - fumarate.
T12738L	Rivanicline	RJR-2403,(E)-Metanicotine	Others
	Rivanicline is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM). It show > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM and IC50 : 26 nM).		Others
T11041	Dihydro-β-erythroidine hydrobromide	DHβE hydrobromide	Others
	Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAC...		Others
T22401	PNU-282987 S enantiomer hydrochloride	(S)-PNU-282987 HCl	Others
	(S)-PNU-282987 is the absolute stereochemistry form of PNU-282987. PNU 282987, a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs) with Ki of 26 nM for the rat receptor, has negligible a...		Others
T23235	RJR-2403 hemioxalate		Others
	RJR-2403 hemioxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM). RJR-2403 hemioxalate > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).		Others
T75927	α-Conotoxin MII TFA
	α-Conotoxin MII TFA (α-CTxMII TFA), a peptide consisting of 16 amino acids derived from the venom of Conus magus, selectively inhibits nicotinic acetylcholine receptors (nAChRs) that are composed of α3β2 subunits, demons...
T80466	κ-Bungarotoxin	κ-Bgt
	κ-Bungarotoxin (κ-Bgt) is a selective and potent antagonist of α3β2 neuronal nicotinic acetylcholine receptors, exhibiting slow reversibility and an IC50 of 2.30 nM [1].
T80481	α-Conotoxin Bt1.8
	α-Conotoxin Bt1.8 is a potent inhibitor of both rat α6/α3β2β3 and α3β2 neuronal nicotinic acetylcholine receptors (nAChRs), exhibiting half-maximal inhibitory concentrations (IC50s) of 2.1 nM for α6/α3β2β3 and 9.4 nM for...